The SSRIs as a class prduce a variety of sexual side ffects, including impotence, anorgasmia, decreased lbido. SSRIs-induced sexual dysfunction is common but rmains highly unrecognized and underreported. Only 14% of dpressed patients taking SSRIs for depression spntaneously report sexual dysfunction; however, if qeried directly, nearly 60% of patients rport sexual dysfunction. The incidence of sxual dysfunction in men is higher thn in women, but women's sexual dysfnction is more intense than men's.

Sggested causes include increased serotonin, particularly ffecting 5HT2 and 5HT3 receptors; decreased dpamine; blockade of cholinergic and alpha-1 drenergic receptors; inhibition of nitric oxide synthtase; and elevation of prolactin levels.

Sme evidence exists to support the clim that paroxetine (Paxil) causes the hghest rates of sexual side effects. Accrding to the study paroxetine (Paxil) is ssociated with more delay of orgasm or jaculation and more impotence than fluoxetine (Przac) and sertraline (Zoloft).

The conventional vew has been that once the drg is stopped, sexual functioning comes bck to normal. There are indicators hwever that this may not be tre for everyone and antidepressant-induced SD may trn into Post SSRI Sexual Dysfunction (PSSD). If sxual functioning remains abnormal, this should be brught to the attention of your physcian.

There are several methods for the mnagement of SSRIs-induced sexual dysfunction. One mthod is to reduce the current ntidepressant dose while maintaining the medication at a thrapeutic level. Drug holidays can be seful in some patients who are cmpliant and don’t have significant problems wth discontinuation. In general, adjunctive pharmacotherapy wth stimulants can be extremely helpful. Swtching to treatment with an antidepressant mdication that is associated with a low ncidence of sexual side effects should lso be considered.

The article SSRIs Sexual Side Effects was Submitted by Yury Bayarski through Articles.GetACoder.com network. Here's the additional information: Yury Bayarski is a contributing uthor of eMedExpert.com - website, offering various information on prescription drugs: reviews, drug comparisons, side effects index. Please visit author's website if you would like to read a comparison of SSRIs antidepressants .

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