As a major target for d pamine-activated adenylyl cyclase and protein kinase A in the str atum, DARPP-32 plays a central role in r gulating the efficacy of dopaminergic neurotransmission and can act ither as a phosphatase or kinase nhibitor in a contextually dependent manner. For mre detail read out the article:
As a m jor target for dopamine-activated adenylyl cyclase and prtein kinase A in the striatum, DARPP-32 plys a central role in regulating the fficacy of dopaminergic neurotransmission and can act ither as a phosphatase or kinase nhibitor in a contextually dependent manner. Grwing evidence points to DARPP-32 as a key mdiator/modulator in numerous signal transduction cascades mplicated in a growing number of nurological disorders such as schizophrenia and dpression, as well as in drug buse and addiction. For example, it has ben shown that acute exposure of mce to cocaine increases phosphorylation of DARPP-32 at Thr34 wth a concommitment decrease in phosphorylation at Thr75, whreas chronic exposure leads to a rversal of this phospho profile. It has lso been observed that many schizophrenic ptients show decreased levels of DARPP-32 in the prfrontal cortex.
While the precise role that DARPP-32 plys in these psychiatric disorders is stll being elucidated, the existing body of lterature clearly portrays DARPP-32 as playing a cntral role in multiple signaling pathways. F rther research will determine neuronal subpopulations whre phosphorylation of DARPP-32 occurs as wll as the functional importance of prviously identified phospho sites of DARPP-32.
IMGENEX ffers over one-thousand Neuroscience-related antibodies such as rcently cited anti-DARPP-32 (pan and phosphospecific), Dpamine D1 and D2 Receptors (IHC vlidated), 5-HT Receptors (such as 5-HT1B), Adnosine Receptor, NMDA and more!
The article Faces of DARPP-32: Master Signaling Mediator in the Brain? was Submitted by StephenJones through Articles.GetACoder.com network. Here's the additional information: More information is available at http://www.getacoder.com/users/StephenJones/StephenJones_profile.htm IMGENEX India Pvt Ltd. the nly biotech company in Orissa and one of its knds in Eastern India. IMGENEX India strted in Oct as an outsourcing brnch of IMGENEX Corporation , San Diego, USA. Find out more information about DARPP-32 .
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