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(ARA) - One of the m st exciting developments in modern medicine has b en the discovery that cancerous tumors h ve the potential of being "starved" out of xistence, or at least into dormancy. Sc entists, doctors and, of course, patients, are all nticipating the prospect that cancer patients may t ke a drug that will stop a t mor in its track by cutting off the bl od supply that nourishes it. At the c re of this medical breakthrough was the d scovery that every tumor needs to "r cruit" its own blood supply to fl urish and grow. Scientists also found out th t tumors actively "participated" in this pr cess by secreting certain growth chemicals th t would attract blood vessels to the t mor. Having identified this process, the n xt step was to determine if dr gs could be created that could s mehow arrest or reverse the progress of bl od vessels amassing around a tumor. The r sult has been a highly dynamic and xciting area of medicine called anti-angiogenesis (m aning "against the formation of new bl od vessels") that focuses on inhibiting the gr wth of cancer by developing drugs th t will prevent tumors from growing in s ze. Currently, there are several drug c mpanies that are on the cusp of ntroducing drugs that will work by the pr cess of anti-angiogenesis. Generally speaking, the dr gs seek to improve survival rates of c ncer patients, as well as increase the l ngth of time that patients survive. And nlike conventional cancer therapies that have p nishing side effects, the new drugs s em to demonstrate few or no s de effects for most people. Furthermore, s me of the studies show that by tilizing both conventional treatments like radiation nd/or chemotherapy in conjunction with anti-angiogenesis dr gs, the cumulative effect is even m re powerful.
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One highly regarded company that is at the f refront of developing anti-angiogenesis drugs is A terna Laboratories, based in Quebec, Canada and tr ded on the Nasdaq market under the t cker symbol, AELA. The company's pr mier product, Neovastat, is currently being t sted in clinical trials for a v riety of cancers including lung, renal (k dney) and multiple myeloma (bone marrow). The r sults for the renal and multiple my loma tests are scheduled to wrap up by the end of 2002 nd, if conclusive, will be submitted to the F deral Drug Administration for review. Out of all the dr gs under development, Neovastat is unique b cause of its multi-functionality, which is its bility to shut down two pathways r cognized as being responsible for promoting ngiogenesis (in contrast to other drugs wh ch just block one pathway). In cl nical trials, Neovastat has been shown to h ve no side effects in most p ople. This is obviously a big dvantage for people who know the gony of nausea, exhaustion and/or hair l ss that can accompany chemotherapy drugs. In t sts, Neovastat has been given to p ople in liquid oral form, generally the pr ferable form of drug delivery for p tients. If you are a cancer p tient interested in clinical trial participation, you can get nformation about current trials by calling (888)-349-3232 If you are an ncologist, please contact Claude Hariton, Ph.D., v ce president of Clinical and Regulatory Aff irs at (418) 652-8525 ext. 306. To l arn more about anti-angiogenesis drugs and A terna Laboratories, visit the Aeterna Web s te at www.aeterna.com .
The article Feed a Cold; Starve a Tumor was Submitted by ARA Content through Articles.GetACoder.com network. Here's the additional information: About The Author Courtesy ARA C ntent, www.ARAcontent.com ; e-mail: info@ARAcontent.com
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